SPONSORED: Announcing the launch of Systane

February 28, 2024 Alcon

Alcon have expanded its range of preservative-free eye drops with the addition of Systane Hydration Multi-Dose Preservative-Free Lubricant Eye Drops.

 

Systane Hydration utilises Systane’s Intelligent Delivery system of HP-Guar and borate in combination with 0.15% hyaluronic acid (HA)* for long-lasting dry eye relief^1-3.

 

Upon instillation, HP-Guar and borate crosslink to form a viscoelastic meshwork⁴. This meshwork forms a mucomimetic bandage over the ocular surface, increasing the retention of demulcents⁵. Additionally, HP-Guar preferentially binds to damaged areas of the cornea, therefore protecting damaged cells to allow for repair and renewal⁵.

 

The combination of HP-Guar and borate with HA has been shown to have an additive effect, providing two times greater moisture retention compared to drops with HA alone in a laboratory study.

 

Systane Hydration has been shown to support healing of the damaged ocular surface, assisting cell viability and regeneration^1,6. The combination of HA and HP-Guar/borate results in greater and faster wound healing (measured in re-epithelialisation) compared to HA alone in a laboratory study⁶.

 

To eliminate the need for preservatives, the bottle features patented PureFlow technology. The bottle has a one-way valve to ensure no contaminated liquid can be re-introduced into the container and a fine silicone membrane to filter returned air⁷. The bottle has a low squeeze force and features a blue tip to aid targeting of the eye for ease of instillation⁷.

 

Systane Hydration is designed to address the symptoms of moderate-severe dry eye^# and can be used for dry eye patients before and after ocular surgery. Approximately 82% of patients experience moderate to severe dry eye symptoms following cataract surgery⁸. Peri-operative management of existing dry eye can reduce post-operative dry eye symptoms and may influence post-operative outcomes^9,10.

 

Systane Hydration Multi-Dose Preservative-Free Lubricant Eye Drops is suitable to use with soft contact lenses. It expires three months after opening.

 

 

* Systane Hydration contains sodium hyaluronate, the salt form of hyaluronic acid.

# Recommendation based upon expected on-eye viscosity 

 

References

1.      Rangarajan R, et al. Effects of a hyaluronic acid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491-497

2.      Davitt W, et al. Efficacy in patients with dry eye after treatment with a new lubricant eye drop formulation. J Ocul Pharmacol Ther. 2010;26(4):347-353

3.      Rolando M, et al. Protecting the ocular surface and improving the quality of life of dry eye patients: a study of the efficacy of an HP-guar containing ocular lubricant in a population of dry eye patients. J Ocul Pharmacol Ther. 2009;25(3):271-278.

4.      Springs C. Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action. Dev Ophthalmol 2010; 45:139-147.

5.      Ng , A, et al. Tear osmolarity changes after use of hydroxypropyl-guar-based lubricating eye drops. Clin Ophthalmol. 2018 Apr 10;12:695-700.

6.      Carlson E, et al. Impact of hyaluronic acid-containing artificial tear products on reepithelialization in an in vivo corneal wound model. J Ocul Pharmacol Ther. 2018;34(4)360-364.

7.      Nemera Novelia product leaflet, 2015. Available: www.nemera.net/wp-content/uploads/2014/06/Brochure_Ophthalmic.pdf  (Accessed 23-Jul-2021)

8.      Jayshree M, et al. A prospective study of dry eye after small incision cataract surgery in rural population of Bagalkot. J Clin Res Ophthalmol 2017;4(2):25–29

9.      Favuzza E, et al. Protecting the ocular surface in cataract surgery: the efficacy of the perioperative use of a hydroxypropyl guar and hyaluronic acid ophthalmic solution. Clin Ophthalmol 2020;14:1769–75.

10.   Chuang J, et al. Preoperative optimization of ocular surface disease before cataract surgery. J Cataract Refract Surg 2017;43(12):1596–607. 

 

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